Sepino, Province of Campobasso, Molise
- Territory: mountainous
- Population: about 1900 inhabitants in 2018
- Zip/postal code: 86017
- Dialing Area Code: +39 0874
- Patron Saint: Santa Cristina on 9-10 January and on 23-24 July
- Frazioni & Localities: Altilia, Brecciosa, Cantoni, Casalene, Collemarraco, Colli, Guadocavalli, Macchie, Pesco San Nicola, Petrilli, Piana d'Olmo, Pilone, Ponte di Tavole, Redealto, Rio Verdaro, Tratturo.
History - Antiquity
In the area of Altilia the Romans built the town called Saepinum at the crossing of two important communication paths, one coming from the Matese and the other the Pescasseroli-Candela tratturo, where they constructed aqueducts and spas.
History - The Middle Ages
In the early 7th century AD, Grimoald I of Benevento moved to present-day Sepino, Isernia and Bojano Bulgar refugees escaping from the Avars; the Bulgars were for many generations a distinctive part of the population, until finally assimilated in their Italian environment. In the 11th century AD Sepino was under the Norman County of Bojano. After the 1456 earthquake also the inhabitants of Castelvecchio moved where today Sepino rises.
History - Modern Times
What to see
- Archeological site of the Roman town Saepinum/Altilia, inhabited up to the fourth century AD, with an outside perimeter of m 1250, surrounded by walls and four doors.
- Archeological site of the Samnite town Saepins in Torrevecchia, of the 4th century BC, a fortress surrounded by cyclopic wars with 3 entrance doors. It was reused in the medieval period, as shown by the ruins of a small church. The acropolis inside was possibly the seat of the Samnite ruler (the "meddix tuticus").
- The spring of "Tre Fontane", whose water is used for kidney problems.
- The church of Santa Cristina, with a mausoleum of bishop Antonio Attilio.