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At Acquapendente, on the Via Cassia, he met with the tragical sight and desolation caused by the pestilence called Black Death. Instead of going on his way and avoiding the contagion, he offered himself as voluntary to assist the sick people kept in the local lazzaretto, where soon after some sudden miraculous healings took place. He proceeded from place to place through Tuscany, Umbria and Latium, stopping wherever he found pestilence-stricken people.
After three years he was in Rome: he found Saint Peter's and other churches utterly deserted, since the Pope's seat was at that time in Avignon. He went north through Rimini, Novara and Piacenza. In Piacenza he became infected with the disease. The plague sign appeared on one leg and, not to burden anybody, he left the town and approached the bank of the Po river, to die there in solitude. Tradition is he took refuge in a hut, where he would have starved, if a stray dog had not brought him a loaf of bread every day and if a miraculous fountain had not sprung out to satisfy his thirst.
From this refuge a rich lord, Gottardo Pallastrelli, took him to his mansion until he recovered completely. After that he left Piacenza and headed north, but in the proximity of Lago Maggiore, at Angera, he was mistaken for aspy and imprisoned for five years, until he died in 1327. Another version says that Rocco went back to his native Montpellier and died there.
San Rocco in Art
During 600 years of worship, in representations the wound came nearer to the knee, which explains why to the protection against pestilence also a protection of knees and junctions was added in popular belief.