About 1180 the Barile Lordship included Villa Sant'Angelo, Tussillo, Casentino and Fontavignone. When the city of Aquila was founded in the latter half of the 13th century the Bariles, in spite their castle was partly destroyed by order of King Charles of Anjou in 1272, did not move to Aquila, choosing instead to settle in the nearby hamlets of Tussillo, Casentino, Fontavignone, Villa S. Angelo.
In 1294 the Barile castle was still standing, as shown in a document of King Charles II on 28 September 1294, where all thelands belonging to the jurisdiction of the new-born city of Aquila were listed, establishing that from then on taxes would be levied only on Aquila, which was in its turn responsible for collecting taxes from its subjects, and 70 lands where mentioned, among them "Barile cum villis".
Until 1420 the castle of Barile enjoyed some independence from Aquila, thanks to the great power of its Lords. A proof of the authority of the family in that period comes from a document dated 1420 where Queen Giovanna II welcomed the Barile messenger to discuss about the mountains and forests under the Barile possession. This autonomy did not however last long, since the Barile family, which moved to Perdicasso to Naples, lost all its representatives in Abruzzo after the extinction of the branch of Bartolomeo Barile, Captain of the Peoples of Abruzzo and Viceroy of Charles I of Anjou in 1269, when Errico his great-grandson married Rosa dell'Aquila in the year 1400 about and did not have male descendants. And that is how in 1481 the castle of Barile became subject to Aquila. In the census of 1508, Barile does not appear independently, but as "Barile alias Tussillo", meaning the castle was by then abandoned and the population had moved to the nearby hamlets.
Here are some of the most important members of the family:
- Nicola Barrile, a Captain of King Charles of Anjou in the Acaja War;
- Giovanni Barile, a counselor and Council President of king Robert of Anjou from 1309 to 1343, and was also Governor of Provence, France;
- Odolina, his sister, stepmother to pope Boniface IX
- Perdicasso, Count of Monte Odorisio, a personal counselor of King Ladislaw of Durazzo, Governor of the Kingdom from 1400 to 1414 and Great Chamberlain of the kingdom;
- Philip, bishop of Capua in the 15th century;
- Pietro called Camisa who was in the 15th century Captain of Naples;
- Giovanni, Judge of the Supreme Court of the Kingdom in 1652
Even after the Abruzzese descendancy was extinct, the family continued to be powerful for centuries in the Kingdom of Naples; in 1517 was accepted in the Order of the Knights of Malta, and built monuments in the church of San Lorenzo, Naples. The Barile families had Baronies in Atripalda, Barrile, Belmonte, Biccari, Casalanguida, Casalbordino, Liscia, Montaguto, Pisiniano, Pomigliano d'Atella, Santangelo a Fasanella and more places, a Countdom in Monteodorisio in 1445, they were Dukes of Caivano in 1623 and of Marianella in 1635, Princes of Capri and Sant'Arcangelo. A branch of the family moved to Caltanissetta with Vito Barrile in the 17th century and passed into the line of the Turolifi Barons.