Great names were Restaino Cantelmo, a Captain of the Kingdom in 1301; Simone Cantelmo, Giustiziere of Terra di Lavoro and Molise in 1320; Antonio Cantelmo who in the War of L'Aquila sided with Fortebraccio da Montone; Andrea, who was a captain in Flanders and Catalonia in 1645; Giuseppe, the first Duke of Popoli, who sided with Charles V and helped defeat the French in Southern Italy. His valiancy in battle earned him great recognition. He refused to follow his uncle, Pope Paolo IV, for loyalty to his king.
In 1607 the Cantelmo family was accepted in the Order of the Knights of Malta. Giuseppe, Prince of Pettorano and Duke of Popoli, was the last member of the hereditary line; he died in 1749 leaving two daughters: the first born married into the Tocco family, the princes of Acaia and Montemiletto, who from then changed their surname to Tocco Cantelmo Stuard. The second- born daughter married into the Carafa family, the princes of Roccella, whose second-born from then on added to their surname that of Cantelmo Stuard.
Monuments in honor of the Cantelmo are in the church of Santa Maria Maggiore, Sant'Agostino and Piedigrotta, Naples ; in Mantua there is a former monastery called Cantelma; the Chiesa del Gesù, Pettorano ; in the churches of San Francesco and Santa Maria del Carmine, Popoli. Always in Popoli the Cantelmo Palace and the Castle, and the Taverna Ducale, built in the mid 14th century by Giovanni Cantelmo.
The military prowess of the family was also praised by Ludovico Ariosto in the 36th Canto of the Orlando Furioso: