About the year 1000 he came to the Valle Peligna (Sulmonese Diocesi) and lived there for some time as a hermit in Prato Cardoso. Here he was visited by the Great Counts of the Marsi, Berardo, Teodino and Randuisio, who begged him to establish also in their territory a monastery, in San Pietro del Lago.
A child named Leone, from the town of Castro, who had been attacked by a very violent fever, recovered at once as soon as he drank the water where the saint man had washed his hands.
Also a lady from an aristocratic family, suffering of hemorrhage, begged him to send her the water where he had washed his hands. Domenico sent her instead some water blessed according to the Church custom, with the words that by that she would be healed, but through her faith. The lady drank the water in faith and was healed.
Domenico was in Cocullo for a short time, and left to the local church one molar tooth and the horseshoe of his female mule, which are still preserved in the church with great devotion. The horseshoe has healing power against animal bites, the tooth on those bitten by poisonous snakes.
On another occasion a wolf had taken away an infant, son of a woodcutter, from his cot, and the parents addressed prayers to the saint to help them. The wolf took the baby back to his cot. The miracle is commemorated on the first Sunday in May with a representation in the forest and the presence of snake-charmers.
At the age of about 80, while travelling towards Tuscolo, he was attacked by a deadly wound in his jaw. Domenico went back to his monastery, gathered the other friars and invited them to keep faith to their rule, then received the sacraments and asked to be left alone. From outside the friars heard Domenico speaking to someone, and a a voice answering to him. When everything was silent, they found him dead, but were certain that an angel had come to help him through the passage. It was 22 January 1031. His body was buried in the monastery that takes his name, in Campania, near the town of Sora.